"PACAP and PAC1 receptor signaling in chronic stress responses: Implications for anxiety-related disorders."
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"Role of pituitary adenylate cyclase-activating polypeptide (PACAP) in the bed nucleus of the stria terminalis (BNST): Involvement in stress and anxiety.”
The anterolateral BNST has been suggested to play an important role in mediating anxiety-like behaviors as well as participating in the behavioral response to stress. Chronic exposure to stress could produce maladaptive anxiety-like behaviors as well as physiological changes in the BNST, which might lead to clinical anxiety disorders. Pituitary adenylate cyclase activating polypeptide (PACAP) a...
متن کاملActivation of MEK/ERK signaling contributes to the PACAP-induced increase in guinea pig cardiac neuron excitability.
Pituitary adenylate cyclase (PAC)-activating polypeptide (PACAP) peptides (Adcyap1) signaling at the selective PAC1 receptor (Adcyap1r1) participate in multiple homeostatic and stress-related responses, yet the cellular mechanisms underlying PACAP actions remain to be completely elucidated. PACAP/PAC1 receptor signaling increases excitability of neurons within the guinea pig cardiac ganglia, an...
متن کاملPACAP is Implicated in the Stress Axes
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a highly conserved pleiotropic neuropeptide that functions as a neurotransmitter, neuromodulator and neurotrophic factor. Accumulating evidence implicates PACAP as an important regulator of both central and/or peripheral components of the stress axes, particularly exposure to prolonged or traumatic stress. Indeed, PACAP and its cogna...
متن کاملNaV-igating the MAP from PACAP to excitement. Focus on “Activation of MEK/ERK signaling
PACAP (pituitary adenylate cyclase activating polypeptide) exerts a variety of 15 physiological effects in the nervous, endocrine, gastrointestinal, immune, and cardiovascular 16 systems. For example, it is a neurotrophic factor; modulates synaptic transmission and cellular 17 excitability; controls metabolic function / energy homeostasis; plays key roles in the 18 coordinated physiological res...
متن کاملPACAP-induced ERK activation in HEK cells expressing PAC1 receptors involves both receptor internalization and PKC signaling.
The pituitary adenylate cyclase-activating polypeptide (PACAP)-selective PAC1 receptor (Adcyap1r1) is a G protein-coupled receptor (GPCR) that activates adenylyl cyclase and PLC. Similar to many other GPCRs, our previous studies showed that the PAC1 receptor is internalized after ligand binding to form signaling endosomes, which recruit additional second messenger pathways. Using a human embryo...
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تاریخ انتشار 2012